Nearest airport is called Aktio airport near the town of Preveza. Flights arrive and depart here on a regular base during the season, from April-October.
Lefkada, which is connected to the mainland by a bridge, is a 20-minute drive from this airport.
Flying to Corfu, Athens or Thessaloniki is a good option. By car it will take you between 4 to 5 hours from Athens and Thessaloniki.
Distance from Lefkada in km:
Igoumenitsa (ferries from Corfu, Italy): 108